PUBLICATIONS

selected publication (full list here)

Microbiotas from Humans with Inflammatory Bowel Disease Alter the Balance of Gut Th17 and RORγt⁺ Regulatory T Cells and Exacerbate Colitis in Mice.

Britton GJ, Contijoch EJ, Mogno I, Vennaro OH, Llewellyn SR, Ng R, Li Z, Mortha A, Merad M, Das A, Gevers D, McGovern DPB, Singh N, Braun J, Jacobs JP, Clemente JC, Grinspan A, Sands BE, Colombel JF, Dubinsky MC, Faith JJ.

Rojas OL, Pröbstel AK, Porfilio EA, Wang AA, Charabati M, Sun T, Lee DSW, Galicia G, Ramaglia V, Ward LA, Leung LYT, Najafi G, Khaleghi K, Garcillán B, Li A, Besla R, Naouar I, Cao EY, Chiaranunt P, Burrows K, Robinson HG, Allanach JR, Yam J, Luck H, Campbell DJ, Allman D, Brooks DG, Tomura M, Baumann R, Zamvil SS, Bar-Or A, Horwitz MS, Winer DA, Mortha A, Mackay F, Prat A, Osborne LC, Robbins C, Baranzini SE, Gommerman JL.

Cell. 2018 Dec 21

 

Neutrophils instruct homeostatic and pathological states in naive tissues.

Casanova-Acebes M, Nicolás-Ávila JA, Li JL, García-Silva S, Balachander A, Rubio-Ponce A, Weiss LA, Adrover JM, Burrows K, A-González N, Ballesteros I, Devi S, Quintana JA, Crainiciuc G, Leiva M, Gunzer M, Weber C, Nagasawa T, Soehnlein O, Merad M, Mortha A, Ng LG, Peinado H, Hidalgo A.

J Exp Med. 2018 Oct 3 (Epub ahead of print)

 

A functional genomics predictive network model identifies regulators of inflammatory bowel disease.

Peters LA, Perrigoue J, Mortha A, Iuga A, (…) Dobrin R, Mayer LF,  Schadt EE

Nat Genetics, 2017 Oct;49(10):1437-1449

 

Deciphering the combinatorial influence of diet and the microbiota on experimental colitis.

Sean R Llewellyn, Graham J Britton, Eduardo J Contijoch, Arthur Mortha, Jean-Frederic Colombel, Ari Grinspan, Jose C Clemente, Miriam Merad, Jeremiah J Faith

Gastroenterology, 2018 Mar;154(4):1037-1046.e2

 

The common mouse protozoa Tritrichomonas muris alters mucosal T cell homeostasis and colitis susceptibility.

Escalante NK, Lemire P, Cruz Tleugabulova M, Prescott D, Mortha A, Streutker CJ, Girardin SE, Philpott DJ, Mallevaey T.

J Exp Med. 2016 Nov 11

 

Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome.

Chudnovskiy A*, Mortha A*, Kana V, Kennard A, Ramirez JD, Rahman A, Remark R, Mogno I, Ng R, Gnjatic S, Amir ED, Solovyov A, Greenbaum B, Clemente J, Faith J, Belkaid Y, Grigg ME, Merad M.

Cell. 2016 Oct 6;167(2):444-456.e14 *equal contribution, Image submission selected for cover

 

A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn’s Disease and Reduces Monocyte Signaling via GMCSF.

Chuang LS, Villaverde N, Hui KY, Mortha A, Rahman A, Levine AP, Haritunians T, Ng SM, Zhang W, Hsu NY, (…) Darvasi A, Plagnol V, Silverberg MS, Muise AM, Brant SR, Daly MJ, Segal AW, Duerr RH, Merad M, McGovern DP, Peter I, Cho JH.

Gastroenterology. 2016 Jul 1;

 

Neutrophil ageing is regulated by the microbiome.

Zhang D, Chen G, Manwani D, Mortha A, Xu C, Faith JJ, Burk RD, Kunisaki Y, Jang JE, Scheiermann C, Merad M, Frenette PS.

Nature. 2015 Sep 24;525(7570):528-32.

 

Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility.

Muller PA, Koscsó B, Rajani GM, Stevanovic K, Berres ML, Hashimoto D, Mortha A, Leboeuf M, Li XM, Mucida D, Stanley ER, Dahan S, Margolis KG, Gershon MD, Merad M, Bogunovic M.

Cell. 2014 Jul 17;158(2):300-13

 

Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis.

Mortha A, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer SP, Yasmine Belkaid Y and Miriam Merad M,

Science. 2014 Mar 28;343(6178):1249288

 

Innate lymphoid cells integrate stromal and immune signals to enhance antibody production by splenic marginal zone B cells.

Magri G, Miyajima M, Bascones S, Mortha A, Puga I, Cassis L, Barra CM, Comerma L, Chudnovskiy A, Gentile M, Llige D, Cols M, Serrano S, Aróstegui JI, Juan M, Yagüe J, Merad M, Fagarasan S and Cerutti A,

Nat Immunol., 2014 Apr;15(4):354-64.

 

Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes.

Hashimoto D, Chow A, Noizat C, Teo P, Beasley MB, Leboeuf M, Becker CD, See P, Price J, Lucas D, Greter M, Mortha A, Boyer SW, Forsberg EC, Tanaka M, van Rooijen N, García-Sastre A, Stanley ER, Ginhoux F, Frenette PS, Merad M.

Immunity. 2013 Apr 18;38(4):792-804.

 

GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells.

Greter M, Helft J, Chow A, Hashimoto D, Mortha A, Agudo-Cantero J, Bogunovic M, Gautier EL, Miller J, Leboeuf M, Lu G, Aloman C, Brown BD, Pollard JW, Xiong H, Randolph GJ, Chipuk JE, Frenette PS, Merad M.

Immunity. 2012 Jun 29;36(6):1031-46

 

Regulated expression of nuclear receptor RORgt confers distinct functional fates to NK cell receptor-expressing RORgt(+) innate lymphocytes.

Vonarbourg C*, Mortha A*, Bui VL, Hernandez PP, Kiss EA, Hoyler T, Flach M, Bengsch B, Thimme R, Hölscher C, Hönig M, Pannicke U, Schwarz K, Ware CF, Finke D, Diefenbach A.

Immunity. 2010 Nov 24;33(5):736-51 *equal contribution

 

RORgammat and commensal microflora are required for the differentiation of mucosal interleukin 22 producing NKp46+ cells.

Sanos SL, Bui VL*, Mortha A*, Oberle K, Heners C, Johner C, Diefenbach A.

Nat Immunol. 2009 Jan;10(1):83-91 *equal contribution